Acebutolol and Immediate Release Melatonin in Treatment of Smith-Magenis Syndrome
نویسندگان
چکیده
منابع مشابه
Circadian rhythm abnormalities of melatonin in Smith-Magenis syndrome.
BACKGROUND Smith-Magenis syndrome (SMS) is a multiple congenital anomalies/mental retardation syndrome associated with a hemizygous deletion of chromosome 17, band p11.2. Characteristic features include neurobehavioural abnormalities such as aggressive and self-injurious behaviour and significant sleep disturbances. The majority of patients have a common deletion characterised at the molecular ...
متن کاملBehavioral disturbance and treatment strategies in Smith-Magenis syndrome
BACKGROUND Smith-Magenis syndrome is a complex neurodevelopmental disorder that includes intellectual deficiency, speech delay, behavioral disturbance and typical sleep disorders. Ninety percent of the cases are due to a 17p11.2 deletion encompassing the RAI1 gene; other cases are linked to mutations of the same gene. Behavioral disorders often include outbursts, attention deficit/hyperactivity...
متن کاملPharmacological treatment of disruptive behavior in Smith-Magenis syndrome.
Smith-Magenis syndrome (SMS) is a complex genetic syndrome caused by an interstitial deletion of chromosome 17p11.2. Children and adults with SMS appear to have unique neurobehavioral problems that include: sleep disturbance, self-injurious and maladaptive behaviors, stereotypies, and sensory integration disorders. We gathered retrospective psychotropic use information from parents or other car...
متن کاملAbilities and attainment in Smith-Magenis syndrome.
This study reports on cognitive abilities and attainment in 29 children and 21 adults with Smith-Magenis syndrome. There were 13 boys and 16 girls aged 6 to 16 years, and nine men and 12 women aged 16 to 52 years. All had mild to severe learning disabilities* with no differences overall between verbal and performance skills, but with a particular profile of cognitive strengths and weaknesses. L...
متن کاملAutism spectrum features in Smith-Magenis syndrome.
Smith-Magenis syndrome (SMS; OMIM 182290) is a neurodevelopmental disorder characterized by a well-defined pattern of anomalies. The majority of cases are due to a common deletion in chromosome 17p11.2 that includes the RAI1 gene. In children with SMS, autistic-like behaviors and symptoms start to emerge around 18 months of age. This study included 26 individuals (15 females and 11 males), with...
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ژورنال
عنوان ژورنال: Journal of Medical Cases
سال: 2015
ISSN: 1923-4155,1923-4163
DOI: 10.14740/jmc2102w